Sphingolipids, Lipotoxic Cardiomyopathy, and Cardiac Failure
نویسندگان
چکیده
منابع مشابه
Macrophages modulate cardiac function in lipotoxic cardiomyopathy.
Diabetes is associated with myocardial lipid accumulation and an increased risk of heart failure. Although cardiac myocyte lipid overload is thought to contribute to the pathogenesis of cardiomyopathy in the setting of diabetes, the mechanism(s) through which this occurs is not well understood. Increasingly, inflammation has been recognized as a key pathogenic feature of lipid excess and diabet...
متن کاملCD36 deficiency rescues lipotoxic cardiomyopathy.
Obesity-related diabetes mellitus leads to increased myocardial uptake of fatty acids (FAs), resulting in a form of cardiac dysfunction referred to as lipotoxic cardiomyopathy. We have shown previously that chronic activation of the FA-activated nuclear receptor, peroxisome proliferator-activated receptor alpha (PPARalpha), is sufficient to drive the metabolic and functional abnormalities of th...
متن کاملA novel mouse model of lipotoxic cardiomyopathy.
Inherited and acquired cardiomyopathies are associated with marked intracellular lipid accumulation in the heart. To test the hypothesis that mismatch between myocardial fatty acid uptake and utilization leads to the accumulation of cardiotoxic lipid species, and to establish a mouse model of metabolic cardiomyopathy, we generated transgenic mouse lines that overexpress long-chain acyl-CoA synt...
متن کاملCeramide is a cardiotoxin in lipotoxic cardiomyopathy.
Ceramide is among a number of potential lipotoxic molecules that are thought to modulate cellular energy metabolism. The heart is one of the tissues thought to become dysfunctional due to excess lipid accumulation. Dilated lipotoxic cardiomyopathy, thought to be the result of diabetes and severe obesity, has been modeled in several genetically altered mice, including animals with cardiac-specif...
متن کاملRiboflavin alleviates cardiac failure in Type I diabetic cardiomyopathy
Heart failure (HF) is a common and serious comorbidity of diabetes. Oxidative stress has been associated with the pathogenesis of chronic diabetic complications including cardiomyopathy. The ability of antioxidants to inhibit injury has raised the possibility of new therapeutic treatment for diabetic heart diseases. Riboflavin constitutes an essential nutrient for humans and animals and it is a...
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ژورنال
عنوان ژورنال: Heart Failure Clinics
سال: 2012
ISSN: 1551-7136
DOI: 10.1016/j.hfc.2012.06.003